Fueling innovation through discovery research
Drug Discovery
Discovery research is the first step in transforming innovative ideas into groundbreaking therapies.
At its core are two key pillars:
Chemistry and Biologics, are both essential for understanding diseases and developing effective treatments. With a world-class team, cutting-edge facilities, and a passion for scientific advancement, we are your trusted partner in discovery research.
Chemistry
The cornerstone of drug innovation
In drug discovery, Chemistry plays a fundamental role in drug discovery, driving the design, synthesis, and optimization of therapeutic molecules.
With expertise in medicinal, synthetic, and process chemistry, along with advanced analytical services, we take a holistic approach to drug development, ensuring quality, efficiency at every stage.
From ideas to molecules
Discovery Chemistry is at the heart of early drug development, focusing on identifying and optimizing novel drug candidates. By integrating computational modeling, high-throughput screening, and rational design, our approach refines molecular properties to enhance potency, selectivity, and drug-like characteristics. Through a systematic process, we transform promising compounds into viable therapeutic candidates, accelerating the path from initial discovery to preclinical development.
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Target Identification & Validation
- Utilizing computational models and experimental validation to select viable drug targets.
Hit Identification & Screening
- Employing diverse screening methods, including HTS, activity screening, and virtual screening.
Lead Optimization
- Conducting SAR studies, AI-driven modeling, and multi-parameter optimization for improved drug properties.
Preclinical Candidate Selection
- Identifying compounds with the ideal profile for preclinical development.
Solving complex challenges
Synthetic Chemistry drives the creation of novel molecules with precise structures and properties. Our capabilities are tailored to tackle the most complex challenges in drug development. From small molecules to intricate scaffolds, we ensure efficient synthesis, optimization, and scalability, supporting every stage of drug discovery with precision and innovation.
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Custom Compound Synthesis
- Production of special reagents, intermediates, reference compounds, impurities, and stable isotope standards.
Specialized Chemistry Techniques
- Expertise in heterocyclic chemistry, asymmetric synthesis, metal-catalyzed reactions, and bioconjugation.
Route Design & Optimization
- Developing efficient, scalable, and sustainable synthetic pathways for complex molecules.
Example:
- Route design and troubleshooting
- Asymmetric synthesis
- Complex Molecules (natural products, & PROTACs, carbohydrates, nucleotides, etc.)
- Complex Ring Systems (b-lactams, macrolides, macrocycles, heterocycles)
- Metal catalyzed coupling reactions (Suzuki, Negishi, Heck, Kumada, Sonogashira, & Buchwald-Hartwig )
- Organoboron chemistry
- Organophosphorus chemistry
- Biocatalysts
- Photoredox reaction
- C-H bond functionalization
Ensuring quality & precision
Analytical Chemistry plays a crucial role in drug discovery, ensuring the identity, purity, and quality of compounds through precise characterization and quality control. By leveraging advanced analytical techniques, we provide critical insights into compound properties, stability, and consistency at every stage of development.
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Compound Characterization
- Structural analysis using NMR, MS, IR, UV-Vis, and elemental analysis.
Purity & Quality Control
- HPLC, UPLC, GC, and SFC methods to verify purity and detect impurities.
Process Analytical Support
- Stability testing, in-process monitoring, and method validation for scalable production.
Advanced Analytical Applications
- Metabolite identification, thermal analysis, and physicochemical property evaluation.
Quality Assurance & Residual Analysis
- Microorganisms, endotoxins, and bioburden testing for safety assurance
- Moisture detection by KF and residual solvent analysis using GC, TGA, and LOD
- Reaction safety evaluation for large-scale processes.
- Reference standard characterization to ensure compliance with regulatory standards
Why choose our chemistry services?
This comprehensive suite of techniques and platforms enables us to provide full-spectrum chemistry services across the drug discovery and development continuum, from hit identification through preclinical candidate selection and beyond to process development.
- Sophisticated capabilities in custom synthesis, complex molecular design, and large-scale preparation.
- Seamless integration of computational chemistry, medicinal chemistry, and synthetic chemistry expertise to deliver breakthrough solutions.
Accelerate drug discovery with our chemistry & analytical expertise
Biologics
Unveiling the future of therapeutics
Biology fuels drug discovery by uncovering disease mechanisms and enabling targeted therapies. From recombinant protein expression to antibody discovery, our advanced technologies and expertise drive faster, more effective therapeutic development.
Streamlining protein expression
Our recombinant protein services ensure the production of high-quality proteins for research and therapeutic applications.
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Protein Expression Systems
- E. coli expression system
- Yeast protein expression system
- Baculovirus expression system
- Mammalian cell protein expression systems
Custom Preparations
- Recombinant kinase preparation
- Recombinant antibody expression
These services provide the foundation for structural and functional studies, enabling rapid and scalable protein production.
Unlocking molecular structures
Understanding the structure of target molecules is critical for rational drug design. Our structural biology platform provides powerful tools for visualizing molecular interactions.
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Protein Crystallization Services
- Screening for crystallization conditions and small-molecule co-crystallization
- Protein crystallization and ligand co-crystallization to support structure-based drug discovery
Advanced Structural Analysis
- Three-dimensional structure analysis for precise molecular modeling
- Fragment-based drug discovery (FBDD) services.
- Selenomethionine (SeMET) medium for structure determination
This platform supports the rational design of potent, selective drug candidates by providing detailed insights into molecular mechanisms.
Unveiling drug interactions
Our in vitro biology services provide comprehensive tools for studying drug activity and mechanisms at the cellular and molecular levels.
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Assay Development
- Cell-level and enzyme-level assays for functional characterization
- High-throughput screening and computer-aided drug design (CADD)
- PROTAC molecular screening for protein degradation technologies
Gene and RNA Therapeutics
- siRNA and mRNA drug discovery platforms
- Gene therapy and cell therapy drug development
Specialized Testing
- Radioisotope analysis (3H, 32P, 35S, 125I, 14C) for in-depth studies
- SPR by using Biacore™ 8K based assays
These capabilities enable us to evaluate therapeutic potential and optimize drug candidates with precision.
Engineering next-gen antibodies
Antibody discovery is a pillar of biologics development. Our antibody discovery platforms support the design and engineering of high-affinity, target-specific antibodies.
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Screening Platforms
- Hybridoma screening platform
- Phage display platform
- single B-cell sequencing
Engineering and Modification
- ADA-positive antibody preparation for immunogenicity studies
- Antibody engineering
- Expression cell line construction
From discovery to optimization, our antibody platform accelerates the development of next-generation biologic therapies.
Why choose our biologics services?
We bring deep expertise and cutting-edge technology to biologic discovery. From concept to IND, our fully integrated solutions drive innovation and compliance.
- Expertise in immunotherapy, oncology, and rare diseases
- Proprietary technologies for accelerated discovery
- Fully integrated pipeline from discovery to IND filing support
- Regulatory-compliant processes for global submissions
Accelerate your biologic discoveries with our expertise
Why Partner With Us?
Seamless collaboration across chemistry & biology for drug discovery
Our chemistry services drive the discovery and development of novel molecular entities, while our biology services validate and advance these discoveries through molecular and cellular insights.
Together, these capabilities provide a robust foundation for accelerating the development of innovative therapies.
Quality and Precision
Rigorous analytics & scientific excellence for reliable results.
End-to-End Support
Streamlining drug discovery from hit-to-lead to antibody discovery.
What set
us apart?
Integrated Expertise
Unified platform for chemistry & advanced biology services.
Tailored Solutions
Customized strategies to meet your unique research and development needs.
