From Molecule to Medicine, Faster, Smarter Chemistry

Medicilon Chemistry: From Discovery to Delivery
At Medicilon, we kickstart drug discovery with a powerful mix of traditional medicinal chemistry and cutting-edge tools including AI-driven design and proprietary libraries. From early discovery to scalable synthesis and analytical support, our integrated approach is built to move your therapies forward - Faster and Smarter.
Overview

Discovery Chemistry: Fueling the First Spark of Innovation

Every great therapy begins with a brilliant idea and robust, smart chemistry to bring it to life. At Medicilon, we offer end-to-end support to accelerate your path from concept to preclinical success, starting with pinpointing and validating biological targets to lay the groundwork for drug discovery.

Core Capabilities

  • Compound Library activity screening
  • Conventional & AI-augmented drug design
  • Structure-activity relationship
  • Hit-to-Lead and lead optimization
  • Preclinical candidate (PCC) identification
Emerging Modalities
  • 300+  linkers
  • 150+ E3 ligands (including spiro cycle linkers, CRBN/VHL ligands)
  • End-to-end linker-payload synthesis
  • DAR optimization
  • Linker synthesis and screening (200+ linkers available)
  • Payload synthesis (30+ available)
Nucleic Acid drug platform
  • Monomer
  • Backbone
  • Lipid delivery system synthesis
Small molecule GLP-1a synthesis

Custom Synthesis

Preparation of standards, impurities, and metabolites
Synthesis of stable isotope internal standards and deuterated compounds
Core services

Synthetic Chemistry

Synthetic chemistry drives the creation of molecules critical to drug development. With over 1,100 chemists and 440,000 ft2 of laboratory space, Medicilon delivers tailor-made synthetic solutions span from mg to kg scale production, delivering precision, scalability, and flexibility. We excel in both fee-for-service (FFS) and full-time equivalent (FTE) models to align with your project’s complexity and pace.

Medicinal Chemistry

 

  • Metabolites & Impurities

 

  • Standards

 

  • Stable isotope internal standards

 

  • Deuterated compounds

Scalable Production

  • Reference compound synthesis

 

  • High-purity samples for in vivo studies

 

  • Mg to Kg-scale synthesis (multi-step route development)

Technology Expertise

  • Asymmetric synthesis

 

  • Complex molecule (e.g., natural products, PROTACs)

 

  • Complex ring system (b-Lactams, Macrolides, Macrocycles)

 

  • Metal catalyzed coupling reactions (Suzuki, Negishi, Heck, Kumada, Sonogashira, Buchwald-Hartwig, etc.)

 

  • Organoboron/organophosphorus chemistry

 

  • Photoredox reactions and C-H bond functionalization

 

  • Biocatalysis

Synthesis examples

Analytical Chemistry

Quality starts with precision. Reliable analytical support is the foundation of regulatory success and R&D efficiency. Medicilon’s analytical chemistry suite ensures the quality and characterization of compounds throughout the development process.

Equipment & Capabilities

Instrument
Type
Bruker, 400MHz
Agilent/Shimadzu/Waters (DAD/VWD/RID/CAD/ELSD)
Waters 2545-QDa150ml/min/Gilson 281 50ml/min
Agilent 5977A/Shimadzu GC-MS 2020
Waters UPCC
Waters SFC80/SFC150/SFC300/SFC600
Thermo Scientific Dionex ICS 5000+
METTLER MP70
PE Spectrum TWO/Lambda 365
  • Purity analysis and impurity profiling

 

  • Structural elucidation and confirmation

 

  • Stability testing and degradation studies

 

  • Method development and validation
  • eCTD-Ready Reports: IND-supportive, SEND-compliant outputs

 

  • Speed & Integrity: Every 10 chemists supported by 1 full analytical suite

 

  • Risk Mitigation: Full IP protection, EHS oversight, and data security policies

Why choose our chemistry services?

At Medicilon, we’re more than a chemistry service provider – we’re your R&D partner.

 

Our expert analytical chemists and state-of-the-art instrumentation ensure accurate, regulatory-compliant results at every step.

From hit discovery to scale-up synthesis and analytical support.

Partner with our chemistry experts to design, synthesize, and validate your next breakthrough compound. With the blend of science, scale, and strategic insight, we are here to accelerate your discovery journey.

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