Table of Contents
1. Allergy test
- Rapid type I mediated by immunoglobulin E (IgE)
- Cytotoxic type or cytolytic type II mediated by IgG
- Immune complex type or vasculitis type III mediated by IgG and IgM
- Late-type or type IV mediated by T lymphocytes.
Skin allergy test
Active systemic anaphylaxis (ASA)
Active cutaneous anaphylaxis (ACA)
Passive cutaneous anaphylaxis (PCA)
2. Irritant test
Acute eye irritation test
Such as an acute eye irritation test aimed at confirming and evaluating whether the test product has an irritating or corrosive effect on the eyes of mammals and its degree to provide the basis for its production and use in safety protection.
Skin irritation test
Vascular irritation test
Intravenous administration is often used for drugs with low bioavailability but needing rapid action, acute patients, and patients who cannot swallow due to coma. Intravenous and intramuscular administration allows the drug to enter the blood circulation directly and act rapidly.
However, the high concentration of drug solution will directly contact the inner wall of blood vessels during intravenous administration, which may cause vascular endothelial damage and trigger adverse reactions such as redness, swelling, heat and pain, and pruritus.
Intramuscular irritation test
Nasal drops and inhalant irritation test
Rectal irritation test, etc.
3. Hemolysis test
4. Skin toxicity test
The toxicity test of skin administration includes:
- Acute toxicity test of skin administration.
- Long-term toxicity test of skin administration.
- Skin irritation test.
- Skin sensitization test.
- Phototoxicity test.
(1) Acute toxicity test for dermal administration
(2) Long-term toxicity test for dermal administration
(3) Skin photoallergy and phototoxicity test
Reference:
[1] Mountford AP, Fisher A, Wilson RA. The profile of IgG1 and IgG2a antibody responses in mice exposed to Schistosoma mansoni. Parasite Immunol (1994) 16:521–7. doi: 10.1111/j.1365-3024.1994.tb00306.x
[2] Chen Huaiguang, Yang Canbang, Chen Xiaorui, Et al. Passive cutaneous anaphylaxis of Asarum injection and its effect on serum IgE. DOI: 10.16809/j.cnki.2096-3653.2019110101